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Updated Date: Thu, 15 Jul 2021 00:00:00 EDT

The monoclonal antibody lecanemab may slow cognitive decline in people with early Alzheimer’s disease but is associated with higher rates of serious adverse events, trial results have shown.Researchers from the US, UK, Canada, Japan, Singapore, Germany, and France conducted a double blind, phase III trial in which 898 people aged 50-90 with early Alzheimer’s disease received lecanemab, while 897 received a placebo. The results, published in the New England Journal of Medicine,1 showed that lecanemab, which is administered by intravenous infusion every two weeks, reduced markers of amyloid and resulted in moderately less decline on measures of cognition and function than placebo after 18 months.The drug’s joint developers, Eisai and Biogen, said lecanemab works by binding to and eliminating toxic amyloid β aggregates thought to contribute to neurodegenerative processes in Alzheimer’s disease.However, experts have emphasised that although the findings are encouraging it is not yet known whether the drug will...

The number of patients having to wait in ambulances outside hospitals in England for more than an hour to be admitted has risen to around 11 000 a week, the highest since records began in 2010, it has been revealed, prompting fears that this is contributing to excess deaths.An analysis of NHS England data carried out by BBC News found that by late November thousands of ambulances were waiting this long every week—equivalent to about one in seven of all arrivals—because of overcrowding inside hospitals. This was despite the expectation that handover should take around 15 minutes.The news came as it was confirmed on 30 November that more than 10 000 ambulance workers have voted to strike across 10 ambulance services in England and Wales, with potential strike dates before Christmas. The action by the GMB and Unison unions is in protest over the government’s imposed 4% pay award.Adrian Boyle,...

Articles in The BMJ this week featuring mills and housing may seem like a throwback, but the problems they raise, from science to social welfare, are very contemporary. The impact of the cost of living crisis is clear for health professionals to see, and, where once poor laws offered relief to people who were disadvantaged, recent law making and spending plans will not do enough for people feeling the “consequences of creaking public services in a nation getting poorer” (doi:10.1136/bmj.o2837).1Housing and heating are matters of direct concern to health professionals, given their effect on the population’s health and wellbeing (doi:10.1136/bmj-2021-06967) and the pressures that are then placed on health and social care (doi:10.1136/bmj.o2863).23 Cold, draughty homes promote ill health (doi:10.1136/bmj.o2480).4 Anny Cullum argues that the housing crisis is an emergency that requires urgent government action (doi:10.1136/bmj.o2600).5 An innovative pilot for GPs to prescribe heating to vulnerable people is being implemented...

The NHS in England significantly underestimated the continuing impact of covid-19 on hospital bed capacity this year, its chief executive has said. Amanda Pritchard said that the ongoing high numbers of patients with covid in hospitals had hindered efforts to tackle the backlog of elective care that had built up during the pandemic.“We’ve been completely wrong on the assumptions about covid,” Pritchard told MPs on the House of Commons Public Accounts Committee on 28 November. “Having made, I think, some ambitious assumptions that the level of covid would be low . . . across the UK, we’ve never had less than 5000 patients in hospitals at any one time this year. Covid has been much higher than expected, and the consequences of that are not just beds with patients in, it’s the impact on sickness of staff.”Pritchard conceded that the NHS was currently behind trajectory on its commitment to increase...

Deep brain stimulation surgery (DBS) for movement disorders has been suspended indefinitely by University Hospitals Birmingham NHS Foundation Trust after an independent review of 22 procedures found poor clinical results, with most patients deriving little or no benefit.The trust commissioned the review from consultant neurosurgeons at King’s College Hospital, London, after a serious incident investigation of a patient who underwent DBS for Parkinson’s disease. The external panel looked at all 22 DBS procedures performed on 21 patients for movement disorders from January 2017 to 1 October 2019. The trust said that a further 130 patients also had or were having their cases reviewed.The independent review found “unacceptable delays” in responding to patients’ concerns, poor team working, and a “neurosurgeon whose technique was poor and failed to change in the light of suboptimal results.” The review panel recommended that DBS for movement disorder should remain suspended indefinitely “until all its conditions...

Optimizing Therapy to Prevent Avoidable Hospital Admissions in Multimorbid Older Adults (OPERAM): cluster randomised controlled trial

The FDA wants to update the definition of the nutrient content claim “healthy” and is studying ways to help you spot foods that qualify to make the claim.

Consumer articles about medical devices.

If cardiac arrest does occur, rapid treatment with a medical device called an automated external defibrillator (AED) can be life-saving.

Consumer articles about over-the-counter and prescription drugs.

The U.S. Food and Drug Administration regulates glucose meters and test strips. Check out this safety information from the FDA including advice on why you shouldn't buy or sell previously owned test strips.

How can you tell if an online pharmacy is operating legally? The FDA’s BeSafeRx site can help you identify and avoid dangerous online pharmacies. The FDA has tips for buying medicines online safely.

Kids aren't just small adults. From diet and nutrition to their reactions to medicine, their bodies are unique. Read these Consumer Updates to learn more.

From blood to vaccines, FDA protects and advances the public health by ensuring that biological products are safe, effective, and available to those who need them. Read these Consumer Updates to learn more.

Timely articles and multimedia content about food and food-safety.

Clinical trials give us important information about the safety and effectiveness of a treatment. Before deciding whether your child should join a clinical trial, learn as much as you can, including the risks and benefits.

Following these safe food-handling practices will help prevent foodborne illness.

Easy-to-understand information about the different types of coronavirus tests

FDA safety experts provide tips to protect your eyes when using cosmetics around the eyes.

Aspirin-containing medicines to treat heartburn, sour stomach, acid indigestion or upset stomach can cause stomach or intestinal bleeding in some people. Aspirin is commonly used to reduce pain and fever, but it can increase the risk of bleeding, including in the stomach and digestive tract.

The FDA is working to answer questions about the science, safety, and quality of products containing cannabis and cannabis-derived compounds, particularly CBD.

Consumer articles from FDA about animal health and veterinary medicine.

Muchas tiendas y sitios web están vendiendo estos lentes decorativos ilegalmente sin receta y ponen su visión en riesgo. Aquí le decimos cómo conseguir de manera segura los ojos de vampiros de Crepúsculo, lentes multicolor, u otros lentes de moda.

From tinsel to table scraps, holiday hazards for pets abound. Here are some tips to help you keep them safe.

The FDA approval process ensures that medicines sold in the U.S. are safe and effective. FDA-approved generic drugs, like their brand counterparts, have met strict approval standards.

Certain UV wands may cause injuries within seconds and alternative disinfection methods should be used. The FDA issued a safety communication alerting consumers about these products.